Our lab is interested in how cell growth is regulated via two protein complexes, TOR-complex 1 and 2, in response to nutrient levels and stresses. Using yeast as a model organism, we aim to:
– identify the molecular regulators upstream of the TOR complexes, primarily by using unbiased genetic screens (a traditional strong suit of yeast).
– identify new small-molecule inhibitors of the TOR complexes using state-of-the-art high-throughput screening.
– identify the effectors downstream of the TOR complexes by determining cellular responses after its inhibition via mass spectrometry and biochemical methods.
– determine the atomic structures of the TOR complexes, upstream regulators and downstream effectors by electron microscopy and X-ray crystallography.
University of Geneva
Michael Plank, PostDoc
Robbie Loewith, Principal Investigator