UNIGE

Groupe LOEWITH

Our lab is interested in how cell growth is regulated via two protein complexes, TOR-complex 1 and 2, in response to nutrient levels and stresses. Using yeast as a model organism, we aim to:

– identify the molecular regulators upstream of the TOR complexes, primarily by using unbiased genetic screens (a traditional strong suit of yeast).

– identify new small-molecule inhibitors of the TOR complexes using state-of-the-art high-throughput screening.

– identify the effectors downstream of the TOR complexes by determining cellular responses after its inhibition via mass spectrometry and biochemical methods.

– determine the atomic structures of the TOR complexes, upstream regulators and downstream effectors by electron microscopy and X-ray crystallography.

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ADRESSE

University of Geneva
Department of Molecular Biology, Sc3 2045b
30, quai Ernest-Ansermet
CH-1211, Geneva 4, Switzerland

 

CONTACT

Michael Plank, PostDoc

Michael.Plank@unige.ch

Robbie Loewith, Principal Investigator

Robbie.Loewith@unige.ch